The 11th International Conference on Biomedical Engineering and Biotechnology (ICBEB 2022)

Abstract: One of the basic strategies in the search for new bioactive agents is inspiration from natural compounds such as cinnamic acid. It is an aromatic acid with a long history of use as an additive in plant fragrances and spices. Its derivatives are important promising substances with great potential in the search for new pharmacologically active agents. Cinnamic acid and its derivatives have attracted the attention of scientists in recent decades due to low toxicity and a wide range of biological activities such as antibacterial, antiviral, anti-inflammatory, cytotoxic, antidiabetic, hepatoprotective, antioxidant, neuroprotective, anxiolytic, and antituberculotic. Recent studies investigating the antimicrobial activities of an extensive series of variously substituted cinnamic anilides have revealed compounds with promising anti-infective potential. Since the introduction of a halogen into the molecule structure is known to increase the anti-invasive activity, new halogenated series of anilides were designed and their properties are discussed in this contribution.

Keywords: multi-target compounds, rational design, cinnamic acid derivatives

Acknowledgements: This study was supported by grant projects UK/289/2022, UK/320/2022 and APVV-17-0373.

Biography: Josef Jampilek completed his Ph.D. degree in Medicinal Chemistry at the Faculty of Pharmacy of the Charles University (Czech Republic) in 2004. In 2004-2011, he worked in expert and managerial posts in the R&D Division of the pharmaceutical company Zentiva (Czech Republic). Prof. Jampilek deepened his professional knowledge at the Medicinal Chemistry Institute of the Heidelberg University (Germany) and at multiple specialized courses. In 2017, he was designated as a Full Professor of Medicinal Chemistry. At present he works at the Faculty of Natural Sciences of the Comenius University in Bratislava (Slovakia), the Institute of Neuroimmunology of the Slovak Academy of Sciences and the Faculty of Science of the Palacky University in Olomouc (Czech Republic). In addition, he is a visiting professor at the University of Silesia in Katowice (Poland) and Hong Kong Baptist University (Hong Kong SAR, China) and an invited professor/expert at various higher educational institutions. He is an author/co-author of more than 30 patents/patent applications, more than 250 peer-reviewed scientific publications, 7 university textbooks, more than 40 chapters in monographs, and many invited lectures at international conferences and workshops. He also received several awards for his scientific results, e.g., from Aventis, Elsevier, Willey, Sanofi and FDA. Prof. Jampílek is also an editor, guest editor and member of the editorial boards of several renowned international scientific journals. Scientific fields of prof. Jampilek are drug design, medicinal chemistry, chemical biology as well as drug delivery nanosystems. The research interests of Prof. Jampilek include design, synthesis, and structure-activity relationships of heterocyclic compounds as anti-infectious, antiproliferative and anti-inflammatory agents as well as agrochemicals. He is also interested in ADME, drug bioavailability and solid-state pharmaceutical analysis.